Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Brugia malayi | jmjC domain containing protein | 0.0064 | 0.0783 | 0.0783 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0297 | 0.1055 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.2812 | 0.2812 |
Trypanosoma cruzi | choline ethanolamine kinase, putative | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0134 | 0.2812 | 0.2812 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.2812 | 0.2812 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0134 | 0.2812 | 0.2812 |
Plasmodium vivax | choline kinase, putative | 0.0381 | 1 | 1 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0381 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0134 | 0.2812 | 1 |
Giardia lamblia | Ethanolamine kinase, putative | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0381 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0064 | 0.0783 | 0.2785 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0297 | 0.1055 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0064 | 0.0783 | 0.0783 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.0783 | 0.0783 |
Onchocerca volvulus | Putative choline\/ethanolamine kinase | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0381 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0003 | 0.0003 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0297 | 0.0297 |
Brugia malayi | jmjC domain containing protein | 0.0064 | 0.0783 | 0.0783 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.05 | 0.05 |
Plasmodium falciparum | choline kinase | 0.0381 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0297 | 0.0297 |
Trypanosoma brucei | choline/ethanolamine kinase | 0.0037 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0297 | 0.0297 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.2812 | 0.2812 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0064 | 0.0783 | 0.0783 |
Loa Loa (eye worm) | carboxylesterase | 0.0134 | 0.2812 | 0.2812 |
Leishmania major | choline kinase | 0.0037 | 0 | 0.5 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0381 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0297 | 0.1055 |
Trypanosoma brucei | choline kinase | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | choline/ethanolamine kinase, putative | 0.0037 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.2812 | 0.2812 |
Echinococcus granulosus | carboxylesterase 5A | 0.0134 | 0.2812 | 0.2812 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0064 | 0.0783 | 0.2785 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0003 | 0.0003 |
Leishmania major | choline/ethanolamine kinase, putative | 0.0037 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.05 | 0.05 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0297 | 0.0297 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0064 | 0.0783 | 0.0783 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0297 | 0.0297 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0003 | 0.0009 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.2812 | 0.2812 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.05 | 0.05 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.2812 | 0.2812 |
Schistosoma mansoni | jumonji domain containing protein | 0.0064 | 0.0783 | 0.2785 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0064 | 0.0783 | 0.0783 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.2812 | 0.2812 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.05 | 0.05 |
Trypanosoma cruzi | choline kinase | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.2812 | 0.2812 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.