Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.2695 | 0.2695 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3787 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2695 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.3787 | 0.3787 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3787 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.2695 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2695 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.2695 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.2695 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.3787 | 0.3787 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.3787 | 0.3787 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2695 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3787 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3787 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3787 | 0.3787 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.3787 | 0.3787 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2695 | 0.2695 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.2695 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2695 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0187 | 0.0187 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.