Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable transmembrane transport protein | 0.103 | 0.1918 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1015 | 0.1882 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1015 | 0.1882 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0512 | 0.0699 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0512 | 0.0699 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.1015 | 0.1882 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0512 | 0.0699 | 0.3717 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1015 | 0.1882 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1015 | 0.1882 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1015 | 0.1882 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0892 | 0.1593 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.4248 | 0.9493 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0512 | 0.0699 | 0.3717 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1015 | 0.1882 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1015 | 0.1882 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.1245 | 0.2425 | 0.0669 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1015 | 0.1882 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0512 | 0.0699 | 0.3717 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4463 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1015 | 0.1882 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0215 | 0 | 0.5 |
Onchocerca volvulus | 0.0892 | 0.1593 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.0512 | 0.0699 | 0.3717 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1015 | 0.1882 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0512 | 0.0699 | 0.3717 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1015 | 0.1882 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4463 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.