Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Receptor family ligand binding region containing protein | 0.0661 | 0.1323 | 0.1122 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0418 | 0.0486 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.1257 | 0.338 | 0.3335 |
Loa Loa (eye worm) | hypothetical protein | 0.0661 | 0.1323 | 0.088 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0661 | 0.1323 | 0.088 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.216 | 0.6498 | 0.6319 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.2336 | 0.7106 | 0.8878 |
Loa Loa (eye worm) | glutamate receptor | 0.2578 | 0.7943 | 0.7838 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.216 | 0.6498 | 0.6929 |
Loa Loa (eye worm) | hypothetical protein | 0.3174 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.2931 | 0.9163 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.3174 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.1014 | 0.2543 | 0.2162 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.1257 | 0.338 | 0.3881 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0661 | 0.1323 | 0.088 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.216 | 0.6498 | 0.6319 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0418 | 0.0486 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.2578 | 0.7943 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.