Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0243 | 0.2746 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0505 | 0.184 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0271 | 0.0989 |
Schistosoma mansoni | glycogen phosphorylase | 0.0105 | 0.1054 | 0.1054 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0243 | 0.2746 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0243 | 0.2746 | 0.2746 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0243 | 0.2746 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0243 | 0.2746 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0243 | 0.2746 | 0.2746 |
Giardia lamblia | Glycogen phosphorylase | 0.0243 | 0.2746 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0271 | 0.0989 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0243 | 0.2746 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0243 | 0.2746 | 0.2746 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0243 | 0.2746 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0505 | 0.184 |
Schistosoma mansoni | glycogen phosphorylase | 0.0243 | 0.2746 | 0.2746 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0505 | 0.184 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0243 | 0.2746 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0105 | 0.1054 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0243 | 0.2746 | 0.2746 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0505 | 0.184 |
Brugia malayi | carbohydrate phosphorylase | 0.0243 | 0.2746 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0243 | 0.2746 | 0.2746 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0105 | 0.1054 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0243 | 0.2746 | 0.2746 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0271 | 0.0271 |
Schistosoma mansoni | glycogen phosphorylase | 0.0243 | 0.2746 | 0.2746 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.