Detailed information for compound 1234407

Basic information

Technical information
  • TDR Targets ID: 1234407
  • Name: (2S)-1-(2-naphthalen-1-ylethyl)-2-(phenylmeth yl)piperazine
  • MW: 330.466 | Formula: C23H26N2
  • H donors: 1 H acceptors: 0 LogP: 4.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)C[C@H]1CNCCN1CCc1cccc2c1cccc2
  • InChi: 1S/C23H26N2/c1-2-7-19(8-3-1)17-22-18-24-14-16-25(22)15-13-21-11-6-10-20-9-4-5-12-23(20)21/h1-12,22,24H,13-18H2/t22-/m0/s1
  • InChiKey: RJQJUPDWOUBTAH-QFIPXVFZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-1-[2-(1-naphthyl)ethyl]-2-(phenylmethyl)piperazine
  • (2S)-2-(benzyl)-1-[2-(1-naphthyl)ethyl]piperazine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0205 0.1617 0.6329
Echinococcus granulosus single minded 2 0.0074 0.0205 0.0626
Schistosoma mansoni jun-related protein 0.0291 0.2555 1
Onchocerca volvulus 0.0281 0.2448 1
Brugia malayi bHLH-PAS transcription factor 0.0074 0.0205 0.0626
Brugia malayi hypothetical protein 0.0336 0.3043 0.9273
Mycobacterium ulcerans putative regulatory protein 0.0074 0.0205 0.5
Echinococcus granulosus jun protein 0.0358 0.3281 1
Echinococcus granulosus geminin 0.0205 0.1617 0.4927
Schistosoma mansoni aryl hydrocarbon receptor 0.01 0.0487 0.1908
Schistosoma mansoni single-minded 0.01 0.0487 0.1908
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0054 0.0164
Echinococcus multilocularis transfer RNA-Lys 0.0074 0.0205 0.0205
Echinococcus multilocularis jun protein 0.0358 0.3281 0.3281
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0358 0.3281 1
Schistosoma mansoni hypothetical protein 0.0291 0.2555 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0054 0.0169
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0358 0.3281 0.3281
Loa Loa (eye worm) hypothetical protein 0.0349 0.3175 1
Brugia malayi PAS domain containing protein 0.01 0.0487 0.1485
Brugia malayi bZIP transcription factor family protein 0.0358 0.3281 1
Loa Loa (eye worm) hypothetical protein 0.0336 0.3043 0.9584
Loa Loa (eye worm) hypothetical protein 0.006 0.0054 0.0169
Schistosoma mansoni hypothetical protein 0.0205 0.1617 0.6329
Echinococcus multilocularis geminin 0.0205 0.1617 0.1617
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2408 0.5
Brugia malayi hypoxia-induced factor 1 0.031 0.2761 0.8414
Brugia malayi hypothetical protein 0.0281 0.2448 0.7461
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0054 0.0164
Loa Loa (eye worm) hypoxia-induced factor 1 0.031 0.2761 0.8695

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.