TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 454.448 | Formula: C24H23FN2O6
H donors: 1 H acceptors: 3 LogP: 2.19 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)[C@H]1[C@H]2COc3c([C@@H]2N2[C@@]1(C)C(=O)Nc1c(C2=O)ccc(c1)F)cc(cc3)OC
InChi: 1S/C24H23FN2O6/c1-4-32-22(29)19-16-11-33-18-8-6-13(31-3)10-15(18)20(16)27-21(28)14-7-5-12(25)9-17(14)26-23(30)24(19,27)2/h5-10,16,19-20H,4,11H2,1-3H3,(H,26,30)/t16-,19-,20+,24-/m1/s1
InChiKey: WDQFJKNWXMSRGC-AYFLJRIOSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	transient receptor potential cation channel, subfamily V, member 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.6471	0.6471
Schistosoma mansoni	tensin	0.006	0.7192	0.7192
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.006	0.7192	0.7192
Schistosoma mansoni	suppressor of cytokine signaling	0.006	0.7192	0.7192
Brugia malayi	Variant SH3 domain containing protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Echinococcus granulosus	expressed conserved protein	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0076	1	1
Echinococcus granulosus	N chimaerin	0.006	0.7192	0.7192
Brugia malayi	Protein kinase domain containing protein	0.0076	1	1
Schistosoma mansoni	tyrosine kinase	0.0076	1	1
Brugia malayi	RhoGAP domain containing protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0017	0.00000033819	0.00000033819
Brugia malayi	SH2 domain containing protein	0.006	0.7192	0.7192
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0017	0.00000033819	1
Echinococcus multilocularis	tensin	0.006	0.7192	0.7192
Loa Loa (eye worm)	SH2 domain-containing protein	0.006	0.7192	0.7192
Echinococcus granulosus	tyrosine protein kinase Srms	0.0076	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0076	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0017	0	0.5
Onchocerca volvulus		0.0076	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0017	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.006	0.7192	0.7192
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.006	0.7192	0.7192
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	1	1
Onchocerca volvulus		0.0076	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0076	1	1
Trypanosoma brucei	protein kinase, putative	0.0017	0	0.5
Schistosoma mansoni	GTPase activating protein	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0076	1	1
Echinococcus granulosus	tyrosine kinase	0.0076	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0076	1	1
Echinococcus granulosus	SHC transforming protein 3	0.006	0.7192	0.7192
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0076	1	1
Plasmodium falciparum	protein kinase, putative	0.0017	0	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.6471	0.6471
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	1	1
Brugia malayi	SH2 domain containing protein	0.006	0.7192	0.7192
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.6471	0.6471
Onchocerca volvulus		0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Brugia malayi	SRC-1	0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.006	0.7192	0.7192
Schistosoma mansoni	tensin-related	0.006	0.7192	0.7192
Brugia malayi	Protein kinase domain containing protein	0.0076	1	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0076	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.006	0.7192	0.7192
Toxoplasma gondii	STE kinase	0.0017	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0017	0.00000033819	0.00000033819
Brugia malayi	SH2 domain containing protein	0.0076	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.6471	0.6471
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	1	1
Brugia malayi	integrin-linked kinase	0.0017	0.00000033819	0.00000033819
Brugia malayi	Variant SH3 domain containing protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	STAT protein	0.006	0.7192	0.7192
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.6471	0.6471
Echinococcus granulosus	c src tyrosine kinase	0.0076	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0076	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.006	0.7192	0.7192
Trypanosoma cruzi	protein kinase, putative	0.0017	0	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.006	0.7192	0.7192
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0076	1	1
Echinococcus multilocularis	SHC transforming protein 3	0.006	0.7192	0.7192
Echinococcus multilocularis	growth factor receptor bound protein 2	0.006	0.7192	0.7192
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Leishmania major	hypothetical protein, conserved	0.0017	0	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0017	0.00000033819	0.00000033819
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0076	1	1
Trypanosoma brucei	Pseudokinase, putative	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.006	0.7192	0.7192
Brugia malayi	SH2 domain containing protein	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0076	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.6471	0.6471
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.006	0.7192	0.7192
Brugia malayi	cytokine inducible SH2-containing protein 5	0.006	0.7192	0.7192
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0017	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0076	1	1
Schistosoma mansoni	protein kinase	0.0017	0.00000033819	0.00000033819
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0017	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0076	1	1
Toxoplasma gondii	protein kinase	0.0017	0	0.5
Echinococcus granulosus	SH2 motif	0.006	0.7192	0.7192
Onchocerca volvulus		0.0017	0.00000033819	0.00000033819
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Onchocerca volvulus		0.006	0.7192	0.7192
Brugia malayi	hypothetical protein	0.0076	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.6471	0.6471
Plasmodium vivax	protein kinase, putative	0.0017	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.006	0.7192	0.7192
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.6471	0.6471
Plasmodium falciparum	protein kinase, putative	0.0017	0	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0076	1	1
Echinococcus multilocularis	integrin linked protein kinase	0.0017	0.00000033819	0.00000033819
Schistosoma mansoni	tyrosine kinase	0.0076	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0076	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.006	0.7192	0.7192
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.006	0.7192	0.7192
Echinococcus granulosus	tyrosine kinase	0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.006	0.7192	0.7192
Echinococcus multilocularis	tensin	0.006	0.7192	0.7192
Echinococcus granulosus	hypothetical protein	0.006	0.7192	0.7192
Echinococcus granulosus	suppressor of cytokine signaling 6	0.006	0.7192	0.7192
Brugia malayi	Protein kinase domain containing protein	0.0076	1	1
Onchocerca volvulus		0.006	0.7192	0.7192
Plasmodium falciparum	protein kinase, putative	0.0017	0	0.5
Brugia malayi	protein-tyrosine kinase	0.0076	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0017	0.00000033819	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Trypanosoma cruzi	protein kinase, putative	0.0017	0	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.006	0.7192	0.7192
Schistosoma mansoni	adapter molecule crk	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0076	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0017	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0076	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0017	0	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.6471	0.6471
Echinococcus granulosus	signal transduction protein lnk realted	0.006	0.7192	0.7192
Schistosoma mansoni	tensin	0.006	0.7192	0.7192
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.006	0.7192	0.7192
Schistosoma mansoni	shc transforming protein	0.006	0.7192	0.7192
Trichomonas vaginalis	TKL family protein kinase	0.0017	0.00000033819	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0076	1	1
Brugia malayi	SH2 domain containing protein	0.006	0.7192	0.7192
Echinococcus multilocularis	SH2 motif	0.006	0.7192	0.7192
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0017	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0076	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0076	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0017	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Schistosoma mansoni	tyrosine kinase	0.0076	1	1
Brugia malayi	Variant SH3 domain containing protein	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0076	1	1
Brugia malayi	Protein kinase domain containing protein	0.0017	0.00000033819	0.00000033819
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.006	0.7192	0.7192
Brugia malayi	STAT protein, DNA binding domain containing protein	0.006	0.7192	0.7192
Schistosoma mansoni	growth factor receptor-bound protein	0.006	0.7192	0.7192
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0017	0	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.006	0.7192	0.7192
Echinococcus granulosus	SH2 domain containing adapter protein F	0.006	0.7192	0.7192
Schistosoma mansoni	vav2	0.006	0.7192	0.7192
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0017	0	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.006	0.7192	0.7192
Entamoeba histolytica	SH2 domain containing protein	0.006	0.7192	0.7192
Trichomonas vaginalis	TKL family protein kinase	0.0017	0.00000033819	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	1	1
Giardia lamblia	Protein 21.1	0.0017	0.00000033819	1
Brugia malayi	Tensin	0.006	0.7192	0.7192
Brugia malayi	SH2 domain containing protein	0.006	0.7192	0.7192
Entamoeba histolytica	ankyrin repeat protein	0.0017	0.00000033819	0.00000033819
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.006	0.7192	0.7192
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0076	1	1
Loa Loa (eye worm)	TK protein kinase	0.0076	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	1	1
Leishmania major	protein kinase, putative	0.0017	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.006	0.7192	0.7192
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.006	0.7192	0.7192
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0076	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0017	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0076	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0076	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.006	0.7192	0.7192
Schistosoma mansoni	hypothetical protein	0.006	0.7192	0.7192
Echinococcus multilocularis	NCK adaptor protein	0.006	0.7192	0.7192
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0076	1	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.006	0.7192	0.7192
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0076	1	1
Echinococcus multilocularis		0.006	0.7192	0.7192
Brugia malayi	SH2 domain containing protein	0.006	0.7192	0.7192
Brugia malayi	Variant SH3 domain containing protein	0.006	0.7192	0.7192
Echinococcus multilocularis	c src tyrosine kinase	0.0076	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0017	0.00000033819	1
Loa Loa (eye worm)	SRC-1	0.0076	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0017	0	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.006	0.7192	0.7192
Onchocerca volvulus		0.006	0.7192	0.7192
Onchocerca volvulus		0.0076	1	1
Schistosoma mansoni	tyrosine kinase	0.0076	1	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.006	0.7192	0.7192
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	hypothetical protein	0.0076	1	1
Schistosoma mansoni	tensin	0.006	0.7192	0.7192
Loa Loa (eye worm)	SH2 domain-containing protein	0.006	0.7192	0.7192
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0076	1	1
Schistosoma mansoni	protein kinase	0.0017	0.00000033819	0.00000033819
Onchocerca volvulus		0.006	0.7192	0.7192
Entamoeba histolytica	protein kinase, putative	0.0017	0.00000033819	0.00000033819
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0076	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.006	0.7192	0.7192
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0076	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0076	1	1
Echinococcus granulosus	SH2 motif	0.006	0.7192	0.7192
Schistosoma mansoni	hypothetical protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	SH2 domain-containing protein	0.006	0.7192	0.7192
Schistosoma mansoni	nck2/grb4	0.006	0.7192	0.7192
Echinococcus multilocularis	SH2 motif	0.006	0.7192	0.7192
Schistosoma mansoni	signal transduction protein lnk-related	0.006	0.7192	0.7192
Brugia malayi	Tyrosine-protein kinase abl-1	0.0076	1	1
Echinococcus multilocularis	SH2 motif	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine kinase	0.0076	1	1
Giardia lamblia	Kinase, NEK	0.0017	0.00000033819	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	hypothetical protein	0.006	0.7192	0.7192
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0017	0.00000033819	0.00000033819
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0017	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.006	0.7192	0.7192
Brugia malayi	SH2 domain containing protein	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0076	1	1
Brugia malayi	SH2 domain containing protein	0.0076	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.006	0.7192	0.7192
Onchocerca volvulus		0.006	0.7192	0.7192
Onchocerca volvulus		0.006	0.7192	0.7192
Schistosoma mansoni	SH2A	0.006	0.7192	0.7192
Brugia malayi	Protein kinase domain containing protein	0.0076	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.006	0.7192	0.7192
Onchocerca volvulus		0.0076	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.006	0.7192	0.7192
Onchocerca volvulus		0.0076	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0076	1	1
Brugia malayi	hypothetical protein	0.006	0.7192	0.7192
Echinococcus granulosus	SH2 domain containing protein 7	0.006	0.7192	0.7192
Entamoeba histolytica	protein kinase, putative	0.006	0.7192	0.7192
Schistosoma mansoni	tensin-related	0.006	0.7192	0.7192
Echinococcus granulosus	NCK adaptor protein	0.006	0.7192	0.7192
Echinococcus granulosus	tyrosine protein kinase Src42A	0.006	0.7192	0.7192
Schistosoma mansoni	tyrosine kinase	0.0076	1	1
Leishmania major	protein kinase, putative	0.0017	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.006	0.7192	0.7192
Schistosoma mansoni	suppressor of cytokine signaling	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0076	1	1
Echinococcus granulosus	tensin	0.006	0.7192	0.7192
Echinococcus multilocularis	tyrosine protein kinase shark	0.0076	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0076	1	1
Echinococcus multilocularis	N chimaerin	0.006	0.7192	0.7192

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.9158 uM	PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	160.6663 uM	PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Potentiators of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1314889

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1235637