Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.2015 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0655 | 0.0655 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.2015 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5675 | 0.5675 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.2015 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.6195 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.6195 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.6195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.2015 | 0.1455 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.2015 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.2015 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.2015 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5675 | 0.906 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0655 | 0.0655 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.6195 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6195 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.6195 | 0.6195 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6195 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.2015 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6195 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6195 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.2015 | 0.2015 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5675 | 0.5371 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.2015 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 10.3225 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.