Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen phosphorylase | 0.0099 | 0.2107 | 0.3267 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0247 | 0.7037 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0058 | 0.0724 | 0.0475 |
Echinococcus granulosus | geminin | 0.0164 | 0.4267 | 0.4267 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.4267 | 0.6616 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0058 | 0.0724 | 0.1123 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.023 | 0.6449 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 0.1092 | 0.0642 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 0.1092 | 0.1692 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0058 | 0.0724 | 0.0724 |
Giardia lamblia | Glycogen phosphorylase | 0.023 | 0.6449 | 1 |
Onchocerca volvulus | 0.0069 | 0.1092 | 0.1086 | |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0069 | 0.1092 | 0.1514 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0439 | 0.068 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.023 | 0.6449 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.023 | 0.6449 | 0.6449 |
Onchocerca volvulus | 0.0069 | 0.1092 | 0.1086 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.6222 | 0.8346 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0099 | 0.2107 | 0.3267 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0058 | 0.0724 | 0.1123 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0247 | 0.7037 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0247 | 0.7037 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0247 | 0.7037 | 0.5 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0247 | 0.7037 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.023 | 0.6449 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0247 | 0.7037 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0247 | 0.7037 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0058 | 0.0724 | 0.1123 |
Echinococcus multilocularis | tumor protein p63 | 0.0336 | 1 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0058 | 0.0724 | 0.1123 |
Brugia malayi | carbohydrate phosphorylase | 0.023 | 0.6449 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0143 | 0.356 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.023 | 0.6449 | 0.7928 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0439 | 0.048 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0058 | 0.0724 | 0.0475 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 0.1092 | 0.0642 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.1476 | 0.2289 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0058 | 0.0724 | 0.0475 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0143 | 0.356 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.023 | 0.6449 | 0.6449 |
Brugia malayi | Probable DNA topoisomerase II | 0.0058 | 0.0724 | 0.1123 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0143 | 0.356 | 1 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0099 | 0.2107 | 0.3267 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0143 | 0.356 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.023 | 0.6449 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.023 | 0.6449 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.023 | 0.6449 | 0.6449 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0058 | 0.0724 | 0.0724 |
Trypanosoma brucei | RNA helicase, putative | 0.008 | 0.1476 | 0.3915 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0069 | 0.1092 | 0.1092 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.023 | 0.6449 | 1 |
Giardia lamblia | Kinase, CDC7 | 0.0069 | 0.1092 | 0.1046 |
Echinococcus granulosus | glycogen phosphorylase | 0.023 | 0.6449 | 0.6449 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.023 | 0.6449 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0085 | 0.1635 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 0.1092 | 0.0642 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0099 | 0.2107 | 0.3267 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.023 | 0.6449 | 0.6449 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0069 | 0.1092 | 0.1092 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0058 | 0.0724 | 0.0933 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.023 | 0.6449 | 0.6449 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0143 | 0.356 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.023 | 0.6449 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.4267 | 0.6616 |
Brugia malayi | Protein kinase domain containing protein | 0.0069 | 0.1092 | 0.1692 |
Echinococcus multilocularis | geminin | 0.0164 | 0.4267 | 0.4267 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.516 uM | Inhibition of Cdc7 | ChEMBL. | 20873740 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.