Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 205.9 uM | Inhibition of His6x-tagged PRMT1-mediated protein arginine methylation expressed in Escherichia coli BL21 (DE3) using H4(1-20) and [14C]-SAM by scintillation counting | ChEMBL. | 20666457 |
IC50 (binding) | = 1200 uM | Inhibition of His6x-tagged PRMT1-mediated protein arginine methylation expressed in Escherichia coli BL21 (DE3) using GAR R4 peptide and [14C]-AdoMet by scintillation counting | ChEMBL. | 20666457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.