Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide S receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | neuropeptide s receptor | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Schistosoma japonicum | IPR000276,Rhodopsin-like GPCR superfamily,domain-containing | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus granulosus | neuropeptide s receptor | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus granulosus | neuropeptide receptor A26 | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus multilocularis | neuropeptide receptor A26 | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0463 | 0.6752 | 1 |
Onchocerca volvulus | 0.0463 | 0.6752 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 0.6752 | 1 |
Onchocerca volvulus | 0.0463 | 0.6752 | 1 | |
Onchocerca volvulus | 0.0463 | 0.6752 | 1 | |
Echinococcus multilocularis | neuropeptide s receptor | 0.0558 | 1 | 0.5 |
Onchocerca volvulus | 0.0463 | 0.6752 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0463 | 0.6752 | 1 |
Onchocerca volvulus | 0.0463 | 0.6752 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0463 | 0.6752 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0558 | 1 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0558 | 1 | 0.5 |
Onchocerca volvulus | 0.0463 | 0.6752 | 1 | |
Onchocerca volvulus | 0.0463 | 0.6752 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0463 | 0.6752 | 1 |
Onchocerca volvulus | 0.0463 | 0.6752 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.