Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isoprenylcysteine carboxyl methyltransferase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.4 uM | Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting | ChEMBL. | 20809634 |
IC50 (functional) | = 27 uM | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by colorimetric tetrazolium assay | ChEMBL. | 20809634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.