Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | vesicle-fusing ATPase | 0.0017 | 0.4584 | 1 |
Mycobacterium ulcerans | ATPase | 0.0017 | 0.4742 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0027 | 0.9326 | 0.9122 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0027 | 0.9326 | 0.5 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.4584 | 1 |
Brugia malayi | valosin containing protein | 0.0017 | 0.4584 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0028 | 1 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0027 | 0.9326 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0028 | 1 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0028 | 1 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0027 | 0.9326 | 0.5 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0017 | 0.4742 | 0.0000097958 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0028 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0027 | 0.9326 | 0.5 |
Giardia lamblia | AAA family ATPase | 0.0017 | 0.4742 | 0.5 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0017 | 0.4584 | 1 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0027 | 0.9326 | 0.5 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0017 | 0.4742 | 0.5 |
Trypanosoma brucei | Valosin-containing protein | 0.0027 | 0.9326 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0027 | 0.9326 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 141.2538 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.