Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0182 | 1 | 0.5 |
Onchocerca volvulus | 0.0182 | 1 | 0.5 | |
Echinococcus granulosus | tissue type plasminogen activator | 0.0182 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0182 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0182 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0182 | 1 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0182 | 1 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0182 | 1 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 44 % | Inhibition of human PrCP at 5 uM by FRET | ChEMBL. | 20857914 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.