Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.067183 | 0.925402 | 1 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0725122 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0724656 | 0.999348 | 0.999348 |
Entamoeba histolytica | protein kinase, putative | 0.0725122 | 1 | 1 |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0409513 | 0.558213 | 0.558213 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0409513 | 0.558213 | 0.603212 |
Schistosoma mansoni | serine/threonine protein kinase | 0.067183 | 0.925402 | 0.925402 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0409513 | 0.558213 | 0.558213 |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.00107296 | 0 | 0.5 |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.00107296 | 0 | 0.5 |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0725122 | 1 | 1 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.00107296 | 0 | 0.5 |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0725122 | 1 | 1 |
Trichomonas vaginalis | pten, drome, putative | 0.00107296 | 0 | 0.5 |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.00107296 | 0 | 0.5 |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 4.1 G protein, putative homolog | 0.00107296 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0725122 | 1 | 1 |
Giardia lamblia | Protein tyrosine phosphatase | 0.00107296 | 0 | 0.5 |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.067183 | 0.925402 | 1 |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0409513 | 0.558213 | 0.558213 |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Onchocerca volvulus | 0.00107296 | 0 | 0.5 | |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0724656 | 0.999348 | 0.999348 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.00107296 | 0 | 0.5 |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.00107296 | 0 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0409513 | 0.558213 | 0.603212 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 10 uM | Antimalarial activity against Plasmodium falciparum | ChEMBL. | 20801038 |
MIC (functional) | Antimicrobial activity against vancomycin-resistant Mycobacterium tuberculosis | ChEMBL. | 20801038 | |
MIC (functional) | > 500 uM | Antimicrobial activity against amphotericin B-resistant Candida albicans | ChEMBL. | 20801038 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20801038 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.