Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | histone deacetylase | 0.0593 | 0.9749 | 1 |
Plasmodium falciparum | peptide deformylase | 0.0472 | 0.4896 | 0.5022 |
Treponema pallidum | polypeptide deformylase (def) | 0.0472 | 0.4896 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0351 | 0 | 0.5 |
Echinococcus granulosus | histone deacetylase 7 | 0.0593 | 0.9749 | 0.9749 |
Brugia malayi | Histone deacetylase family protein | 0.0593 | 0.9749 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0351 | 0 | 0.5 |
Plasmodium vivax | histone deacetylase, putative | 0.0593 | 0.9749 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0472 | 0.4896 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0593 | 0.9749 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0593 | 0.9749 | 0.9749 |
Giardia lamblia | Histone deacetylase | 0.0351 | 0 | 0.5 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0593 | 0.9749 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0593 | 0.9749 | 0.9749 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0593 | 0.9749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.3088 | 0.3168 |
Plasmodium falciparum | histone deacetylase 2 | 0.0593 | 0.9749 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0351 | 0 | 0.5 |
Chlamydia trachomatis | peptide deformylase | 0.0472 | 0.4896 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0599 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0472 | 0.4896 | 0.5022 |
Mycobacterium ulcerans | peptide deformylase | 0.0472 | 0.4896 | 0.5 |
Trypanosoma brucei | histone deacetylase 3 | 0.0593 | 0.9749 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0593 | 0.9749 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0351 | 0 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0593 | 0.9749 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0351 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0472 | 0.4896 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0593 | 0.9749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0434 | 0.3339 | 0.3425 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0593 | 0.9749 | 0.9749 |
Echinococcus granulosus | histone deacetylase | 0.0593 | 0.9749 | 0.9749 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0351 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0472 | 0.4896 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0593 | 0.9749 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0472 | 0.4896 | 0.5022 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0351 | 0 | 0.5 |
Trypanosoma brucei | histone deacetylase, putative | 0.0593 | 0.9749 | 1 |
Leishmania major | histone deacetylase, putative | 0.0593 | 0.9749 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0351 | 0 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0593 | 0.9749 | 0.9749 |
Plasmodium falciparum | histone deacetylase, putative | 0.0593 | 0.9749 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0593 | 0.9749 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0351 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0351 | 0 | 0.5 |
Trypanosoma brucei | histone deacetylase 4 | 0.0593 | 0.9749 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0593 | 0.9749 | 0.9749 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0593 | 0.9749 | 0.9749 |
Echinococcus granulosus | histone deacetylase 6 | 0.0593 | 0.9749 | 0.9749 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0599 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0593 | 0.9749 | 0.9749 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Antibacterial activity against Escherichia coli M17 assessed as bacterial growth inhibition | ChEMBL. | 20850304 | |
Inhibition (binding) | Inhibition of Mycobacterium tuberculosis MenB expressed in Escherichia coli BL21 (DE3) up to 100 uM by double-reciprocal plot analysis | ChEMBL. | 20850304 | |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv after 5 to 7 days by alamar blue assay | ChEMBL. | 20850304 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.