Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0064695 | 0.0930707 | 0.0930707 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0156259 | 0.351711 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064695 | 0.0930707 | 0.0930707 |
Onchocerca volvulus | Dual oxidase homolog | 0.0031746 | 0 | 0.5 |
Onchocerca volvulus | 0.0031746 | 0 | 0.5 | |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.00763917 | 0.12611 | 0.546989 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.00946396 | 0.177655 | 0.177655 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.00532054 | 0.060616 | 0.153034 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0103054 | 0.201422 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0031746 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.00946396 | 0.177655 | 0.177655 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0321072 | 0.817257 | 1 |
Onchocerca volvulus | 0.0031746 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.00763917 | 0.12611 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0321072 | 0.817257 | 1 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0156259 | 0.351711 | 0.5 |
Onchocerca volvulus | 0.0031746 | 0 | 0.5 | |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.00763917 | 0.12611 | 0.546989 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0156259 | 0.351711 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0031746 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0031746 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0031746 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0385767 | 1 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.00532054 | 0.060616 | 0.153034 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0031746 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0385767 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0064695 | 0.0930707 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = -5 | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | ChEMBL. | 19734910 |
IC50 (functional) | = -5 | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | ChEMBL. | 19734910 |
IC50 (functional) | = -5 | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | ChEMBL. | 19734910 |
IC50 (functional) | = -5 | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | ChEMBL. | 19734910 |
IC50 (functional) | = -4.9 | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | ChEMBL. | 19734910 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 19734910 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.