Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isoprenylcysteine carboxyl methyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0139 | 1 | 1 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0139 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0194 | 0.0194 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0711 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0711 | 0.0528 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0194 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0711 | 0.0528 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.1786 | 0.1624 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0139 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1786 | 0.1624 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1786 | 0.1624 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.1463 | 0.3687 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0139 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.1786 | 0.1624 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0139 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.4734 | 0.463 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1786 | 0.1624 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0139 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.4734 | 0.463 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0139 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1786 | 0.1624 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0139 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1786 | 0.1624 |
Mycobacterium ulcerans | hypothetical protein | 0.0061 | 0.3636 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.1786 | 0.1624 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0139 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1786 | 0.1624 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1786 | 0.1624 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0139 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0711 | 0.0528 |
Brugia malayi | Inositol-1 | 0.0038 | 0.1786 | 0.1786 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.1786 | 0.1624 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0711 | 0.0528 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.1786 | 1 |
Echinococcus multilocularis | 0.0139 | 1 | 1 | |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.1786 | 0.1624 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.4734 | 0.463 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0139 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.4734 | 0.463 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0139 | 1 | 1 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0139 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.1786 | 0.1624 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1786 | 0.1624 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.4734 | 0.463 |
Brugia malayi | hypothetical protein | 0.0074 | 0.4734 | 0.4734 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0139 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0711 | 0.0711 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.1786 | 0.4626 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.4734 | 0.463 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0711 | 0.0528 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0711 | 0.0528 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0061 | 0.3636 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.1463 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.4734 | 0.463 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0711 | 0.0528 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0139 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.4734 | 0.463 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0711 | 0.0528 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0139 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.1 uM | Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting | ChEMBL. | 20809634 |
IC50 (binding) | = 4.42 uM | Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-biotin-S-farnesyl-L-cysteine after 30 mins | ChEMBL. | 23514631 |
IC50 (functional) | = 7.2 uM | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by colorimetric tetrazolium assay | ChEMBL. | 20809634 |
IC50 (functional) | = 7.36 uM | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay | ChEMBL. | 23514631 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20809634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.