Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isoprenylcysteine carboxyl methyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0139 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0139 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0139 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0711 | 0.0711 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0711 | 0.0528 |
Mycobacterium ulcerans | hypothetical protein | 0.0061 | 0.3636 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0711 | 0.0528 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0139 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1786 | 0.1624 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1786 | 0.1624 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.1786 | 0.1624 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0139 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.1786 | 0.1624 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.1463 | 0.3687 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0139 | 1 | 1 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0139 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0074 | 0.4734 | 0.4734 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.1786 | 0.4626 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.1786 | 0.1624 |
Brugia malayi | Inositol-1 | 0.0038 | 0.1786 | 0.1786 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0711 | 0.0528 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0711 | 0.0528 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.4734 | 0.463 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1786 | 0.1624 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0194 | 0.0194 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0139 | 1 | 1 |
Echinococcus multilocularis | 0.0139 | 1 | 1 | |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.1786 | 0.1624 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.1463 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0711 | 0.0528 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.4734 | 0.463 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1786 | 0.1624 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0711 | 0.0528 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0139 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0711 | 0.0528 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1786 | 0.1624 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.1786 | 0.1624 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0139 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1786 | 0.1624 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.4734 | 0.463 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.1786 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0061 | 0.3636 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.4734 | 0.463 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0139 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0194 | 0.5 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0139 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1786 | 0.1624 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.4734 | 0.463 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.1786 | 0.1624 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.4734 | 0.463 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0711 | 0.0528 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0139 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0711 | 0.0528 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.4734 | 0.463 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0139 | 1 | 1 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0139 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.4734 | 0.463 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0139 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1786 | 0.1624 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.1 uM | Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting | ChEMBL. | 20809634 |
IC50 (binding) | = 4.42 uM | Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-biotin-S-farnesyl-L-cysteine after 30 mins | ChEMBL. | 23514631 |
IC50 (functional) | = 7.2 uM | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by colorimetric tetrazolium assay | ChEMBL. | 20809634 |
IC50 (functional) | = 7.36 uM | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay | ChEMBL. | 23514631 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20809634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.