Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Plasmodium vivax | apical sushi protein, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Plasmodium falciparum | apical sushi protein | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.4835 | 0.4835 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0015 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 67.63 % | Antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis assessed as reduction of relative light unit at 1 ug/ml after 72 hrs by luciferase reporter phage assay relative to control | ChEMBL. | 20822833 |
Activity (functional) | = 75.08 % | Antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis assessed as reduction of relative light unit at 2 ug/ml after 72 hrs by luciferase reporter phage assay relative to control | ChEMBL. | 20822833 |
MIC (functional) | = 50 ug ml-1 | Antifungal activity against Candida albicans-6 NCIM C27 after 72 to 96 hrs by twofold serial dilution method | ChEMBL. | 20822833 |
MIC (functional) | = 50 ug ml-1 | Antifungal activity against Candida albicans NCIM C27 after 72 to 96 hrs by twofold serial dilution method | ChEMBL. | 20822833 |
MIC (functional) | = 50 ug ml-1 | Antifungal activity against Candida albicans-51 NCIM C27 after 72 to 96 hrs by twofold serial dilution method | ChEMBL. | 20822833 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Escherichia coli NCIM 2345 after 24 hrs by twofold serial dilution method | ChEMBL. | 20822833 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.