Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4E | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.1587 | 0.1587 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0304 | 0.2935 | 0.4758 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.1587 | 0.2573 |
Brugia malayi | Hemopexin family protein | 0.031 | 0.3022 | 0.49 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0304 | 0.2935 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.225 | 0.3647 |
Mycobacterium ulcerans | hydrolase | 0.0304 | 0.2935 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.1587 | 0.1587 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0553 | 0.6081 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0863 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.225 | 0.3647 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.1587 | 0.2573 |
Onchocerca volvulus | 0.031 | 0.3022 | 0.448 | |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0249 | 0.225 | 0.7443 |
Loa Loa (eye worm) | matrixin family protein | 0.0553 | 0.6081 | 0.9858 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0252 | 0.2282 | 0.7551 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0249 | 0.225 | 0.3647 |
Brugia malayi | Matrixin family protein | 0.0249 | 0.225 | 0.3647 |
Brugia malayi | Matrixin family protein | 0.0249 | 0.225 | 0.3647 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.1241 | 0.4106 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.225 | 0.3647 |
Schistosoma mansoni | hypothetical protein | 0.031 | 0.3022 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0249 | 0.225 | 0.3085 |
Brugia malayi | Matrixin family protein | 0.0249 | 0.225 | 0.3647 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.2935 | 0.4758 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0304 | 0.2935 | 0.5 |
Brugia malayi | Matrixin family protein | 0.056 | 0.6168 | 1 |
Brugia malayi | Matrixin family protein | 0.0249 | 0.225 | 0.3647 |
Loa Loa (eye worm) | matrixin family protein | 0.056 | 0.6168 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.1587 | 0.1587 |
Onchocerca volvulus | 0.0249 | 0.225 | 0.3085 | |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.1241 | 0.4106 |
Onchocerca volvulus | Matrilysin homolog | 0.0553 | 0.6081 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.4125 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.4932 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.