Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0208 | 0.2179 | 0.3482 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0253 | 0.2826 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0461 | 0.5793 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0253 | 0.2826 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0503 | 0.6386 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.2179 | 0.3412 |
Loa Loa (eye worm) | matrixin family protein | 0.0503 | 0.6386 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0756 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0208 | 0.2179 | 0.3412 |
Loa Loa (eye worm) | matrixin family protein | 0.0461 | 0.5793 | 0.9071 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0253 | 0.2826 | 0.4425 |
Brugia malayi | Matrixin family protein | 0.0208 | 0.2179 | 0.3412 |
Schistosoma mansoni | hypothetical protein | 0.0295 | 0.3419 | 0.5463 |
Brugia malayi | Matrixin family protein | 0.0208 | 0.2179 | 0.3412 |
Brugia malayi | Hemopexin family protein | 0.0295 | 0.3419 | 0.5354 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.2179 | 0.3412 |
Brugia malayi | Matrixin family protein | 0.0208 | 0.2179 | 0.3412 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.2179 | 0.3412 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0253 | 0.2826 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0461 | 0.5793 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0208 | 0.2179 | 0.3412 |
Onchocerca volvulus | 0.0295 | 0.3419 | 0.3431 | |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.2826 | 0.4425 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0494 | 0.6259 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0891 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.