Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.9564 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.9564 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0095 | 0.0008 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.9564 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.9564 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0124 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0124 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3649 | 0.3759 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3649 | 0.3759 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3649 | 0.3759 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3649 | 0.3759 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0124 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3649 | 0.3759 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0087 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3649 | 0.3759 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.9564 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.9564 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.0124 | 1 |
Brugia malayi | Matrixin family protein | 0.0095 | 0.0008 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0087 | 0 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.9564 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3649 | 0.3759 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.9564 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.7079 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 2.0596 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.