Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3308 | 0.3308 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0132 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3308 | 0.3308 |
Onchocerca volvulus | Lysosome membrane protein 2 homolog | 0.0084 | 0.3308 | 0.5 |
Brugia malayi | CD36 family protein | 0.0084 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0132 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0132 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0084 | 0.3308 | 0.3308 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3308 | 0.3308 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0132 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0084 | 0.3308 | 0.3308 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3308 | 0.3308 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.