Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.0039 | 0.3872 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0083 | 1 | 1 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0039 | 0.3872 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0011 | 0 | 0.5 |
Leishmania major | ferric reductase, putative | 0.0039 | 0.3872 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0083 | 1 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0039 | 0.3872 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins | ChEMBL. | 21036612 |
EC50 (functional) | > 100 uM | Binding affinity at mGluR4 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins | ChEMBL. | 21036612 |
Ki (binding) | > 100 uM | Displacement of [3H]CGP39653 from NMDA receptor in Sprague-Dawley rat brain cortex after 60 mins by competitive binding assay | ChEMBL. | 21036612 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.