Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0083 | 0.358 | 0.358 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.2218 | 0.6193 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.195 | 0.195 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.358 | 0.358 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.2218 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.195 | 0.195 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.358 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.358 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.358 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.195 | 0.8794 |
Brugia malayi | hypothetical protein | 0.0083 | 0.358 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1191 | 0.3327 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.195 | 0.5446 |
Echinococcus multilocularis | geminin | 0.0198 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.195 | 0.195 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.2218 | 0.6193 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0083 | 0.358 | 0.358 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1191 | 0.5371 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0083 | 0.358 | 0.358 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1191 | 0.1191 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.358 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.195 | 0.195 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.195 | 0.195 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2218 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.195 | 0.195 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.195 | 0.195 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 20 ug ml-1 | Cytotoxicity against human HeLa cells assessed as minimum concentration required to cause microscopically detectable alteration after 2 days | ChEMBL. | 20724039 |
Activity (ADMET) | > 100 ug ml-1 | Cytotoxicity against human HEL cells assessed as minimum concentration required to cause microscopically detectable alteration after 2 days | ChEMBL. | 20724039 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.