Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) | Diphosphomevalonate decarboxylase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Cuticle collagen 6 homolog | Diphosphomevalonate decarboxylase | 317 aa | 317 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0092 | 1 | 1 |
Brugia malayi | diphosphomevalonate decarboxylase family protein | 0.0057 | 0.422 | 0.2431 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2381 | 0.1792 |
Trichomonas vaginalis | diphosphomevalonate decarboxylase, putative | 0.0057 | 0.422 | 0.4979 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0082 | 0.8336 | 0.8207 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.2363 | 0.2714 |
Schistosoma mansoni | chromobox protein | 0.0082 | 0.8336 | 0.7121 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0092 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.2363 | 0.2714 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 1 | 1 |
Onchocerca volvulus | 0.0057 | 0.422 | 1 | |
Trypanosoma cruzi | mevalonate-diphosphate decarboxylase, putative | 0.0057 | 0.422 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0049 | 0.2941 | 0.6351 |
Brugia malayi | Heterochromatin protein 1 | 0.0082 | 0.8336 | 0.7821 |
Echinococcus multilocularis | chromobox protein 1 | 0.0082 | 0.8336 | 0.7121 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.006 | 0.4744 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2363 | 0.1773 |
Trypanosoma cruzi | mevalonate-diphosphate decarboxylase, putative | 0.0057 | 0.422 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0082 | 0.8336 | 0.7121 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0092 | 1 | 1 |
Giardia lamblia | Diphosphomevalonate decarboxylase | 0.0057 | 0.422 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 1 | 0.5 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0092 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 1 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0092 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0092 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 1 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.006 | 0.4744 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.2941 | 0.3419 |
Echinococcus granulosus | chromobox protein 1 | 0.0082 | 0.8336 | 0.7121 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0092 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0082 | 0.8336 | 0.7121 |
Trichomonas vaginalis | chromobox protein, putative | 0.0082 | 0.8336 | 1 |
Leishmania major | mevalonate-diphosphate decarboxylase, putative | 0.0057 | 0.422 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.006 | 0.4744 | 0.4744 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 1 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0092 | 1 | 1 |
Trypanosoma brucei | mevalonate-diphosphate decarboxylase | 0.0057 | 0.422 | 0.5 |
Loa Loa (eye worm) | diphosphomevalonate decarboxylase | 0.0046 | 0.2381 | 0.1792 |
Trypanosoma brucei | mevalonate diphosphate decarboxylase | 0.0057 | 0.422 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.2941 | 0.3419 |
Trichomonas vaginalis | chromobox protein, putative | 0.0082 | 0.8336 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.006 | 0.4744 | 0.0907 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.2363 | 0.4699 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 1 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.006 | 0.4744 | 0.0907 |
Echinococcus multilocularis | chromobox protein 1 | 0.0082 | 0.8336 | 0.7121 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.68 um | PUBCHEM_BIOASSAY: Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC - Secondary Assay. (Class of assay: confirmatory) [Related pubchem assays: 549, 556, 550, 557, 555, 1000, 539 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.