Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0185 | 0.2776 | 0.5004 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0254 | 0.5546 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0254 | 0.5546 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.308 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0115 | 0 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0185 | 0.2776 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0185 | 0.2776 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0115 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.5546 | 1 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0185 | 0.2776 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.308 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0115 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.5546 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0185 | 0.2776 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0185 | 0.2776 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0254 | 0.5546 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0185 | 0.2776 | 0.5004 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0115 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0254 | 0.5546 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1585 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.