Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0211 | 0.9982 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1578 | 0.1578 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0084 | 0.2883 | 0.2501 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0206 | 0.9726 | 0.9726 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0211 | 0.9982 | 1 |
Onchocerca volvulus | 0.0211 | 0.9982 | 0.9982 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0516 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.8279 | 0.8279 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.8279 | 0.8029 |
Toxoplasma gondii | kringle domain-containing protein | 0.0211 | 0.9982 | 0.5 |
Brugia malayi | hypothetical protein | 0.0056 | 0.1344 | 0.1344 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1578 | 0.1578 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.1344 | 0.0874 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.1344 | 0.0874 |
Brugia malayi | Trypsin family protein | 0.0056 | 0.1344 | 0.1344 |
Onchocerca volvulus | 0.0056 | 0.1344 | 0.1344 | |
Brugia malayi | Trypsin family protein | 0.0056 | 0.1344 | 0.1344 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0211 | 0.9982 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0211 | 0.9982 | 0.9982 |
Schistosoma mansoni | hypothetical protein | 0.0211 | 0.9982 | 1 |
Onchocerca volvulus | 0.0206 | 0.9726 | 0.9726 | |
Brugia malayi | Trypsin family protein | 0.0056 | 0.1344 | 0.1344 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.8279 | 0.8279 |
Echinococcus multilocularis | geminin | 0.0205 | 0.963 | 0.9593 |
Brugia malayi | SEA domain containing protein | 0.0206 | 0.9726 | 0.9726 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0481 | 0.0481 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.963 | 0.9629 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.9726 | 0.9726 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Mycobacterium ulcerans | hypothetical protein | 0.0056 | 0.1344 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0056 | 0.1344 | 0.1344 |
Brugia malayi | Protein kinase domain containing protein | 0.0211 | 0.9982 | 0.9982 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1344 | 0.1344 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1344 | 0.1344 |
Onchocerca volvulus | 0.0206 | 0.9726 | 0.9726 | |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.8279 | 0.8029 |
Onchocerca volvulus | 0.0056 | 0.1344 | 0.1344 | |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Loa Loa (eye worm) | trypsin family protein | 0.0056 | 0.1344 | 0.1344 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0211 | 0.9982 | 0.9982 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1344 | 0.1344 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0056 | 0.1344 | 0.0874 |
Leishmania major | hypothetical protein, conserved | 0.0211 | 0.9982 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0211 | 0.9982 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.8279 | 0.8279 |
Onchocerca volvulus | 0.0056 | 0.1344 | 0.1344 | |
Onchocerca volvulus | 0.0206 | 0.9726 | 0.9726 | |
Echinococcus granulosus | geminin | 0.0205 | 0.963 | 0.9593 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.963 | 0.9629 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1344 | 0.1344 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0056 | 0.1344 | 0.1344 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1344 | 0.1344 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 0.9726 | 0.9729 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.9982 | 0.9982 |
Onchocerca volvulus | 0.0211 | 1 | 1 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0516 | 0.0516 |
Onchocerca volvulus | 0.0206 | 0.9726 | 0.9726 | |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1578 | 0.1578 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Onchocerca volvulus | 0.0056 | 0.1344 | 0.1344 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0065 | 0.1825 | 0.1383 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1578 | 0.1578 |
Onchocerca volvulus | 0.0056 | 0.1344 | 0.1344 | |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1344 | 0.1344 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.8279 | 0.8029 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0211 | 0.9982 | 1 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0056 | 0.1344 | 0.1344 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Onchocerca volvulus | 0.0056 | 0.1344 | 0.1344 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0056 | 0.1344 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1344 | 0.1344 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.