Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0443 | 0.0511 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4429 | 0.4844 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1132 | 0.1305 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0513 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.151 | 0.2221 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.0762 | 0.0762 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0762 | 0.0665 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0443 | 0.0104 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0036 | 0.0762 | 0.0879 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0113 | 0.4429 | 0.5107 |
Echinococcus granulosus | GPCR family 2 | 0.0036 | 0.0762 | 0.0762 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.5245 | 0.5835 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.151 | 0.2221 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.5245 | 0.5835 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0513 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1132 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 1 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.151 | 0.2221 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0113 | 0.4429 | 0.4844 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5245 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1132 | 0.1435 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.8673 | 1 |
Brugia malayi | RNA binding protein | 0.013 | 0.5245 | 0.6048 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.151 | 0.1741 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0513 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.0762 | 0.0762 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.5245 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.151 | 0.2221 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1132 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0762 | 0.0665 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0513 | 0.0085 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.0762 | 0.0665 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5245 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.151 | 0.2303 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0762 | 0.0665 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0513 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0036 | 0.0762 | 0.0879 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1132 | 0.5 |
Brugia malayi | TAR-binding protein | 0.013 | 0.5245 | 0.6048 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1132 | 0.1435 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0113 | 0.4429 | 0.5107 |
Brugia malayi | hypothetical protein | 0.003 | 0.0513 | 0.0592 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1132 | 0.1524 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.151 | 0.2221 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.2732 | 0.4767 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0762 | 0.0388 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0513 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5245 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5245 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0077 | 0.2732 | 0.315 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0513 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.5245 | 0.5835 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0762 | 0.0665 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.5245 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1132 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.8673 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1132 | 0.1435 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.151 | 0.1296 |
Echinococcus multilocularis | GPCR, family 2 | 0.0036 | 0.0762 | 0.0665 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0513 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2732 | 0.2781 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.5245 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.151 | 0.2303 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.5245 | 0.6048 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0513 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0036 | 0.0762 | 0.0388 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.0762 | 0.0665 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.