Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | growth factor receptor-bound protein | 0.0031 | 0.0129 | 0.0131 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0343 | 0.3826 | 0.3826 |
Leishmania major | choline kinase | 0.0033 | 0.0156 | 0.5 |
Plasmodium falciparum | choline kinase | 0.0343 | 0.3826 | 1 |
Plasmodium vivax | choline kinase, putative | 0.0343 | 0.3826 | 1 |
Leishmania major | choline/ethanolamine kinase, putative | 0.0033 | 0.0156 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0417 | 0.0425 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0035 | 0.0181 | 0.0181 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0033 | 0.0156 | 0.0407 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0417 | 0.0425 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0417 | 0.0425 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0033 | 0.0156 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0035 | 0.0181 | 0.0181 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0343 | 0.3826 | 0.3826 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0035 | 0.0181 | 0.0181 |
Schistosoma mansoni | tyrosine kinase | 0.0035 | 0.0181 | 0.0184 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0044 | 0.2856 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0343 | 0.3826 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0049 | 0.0128 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0035 | 0.0181 | 0.0181 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0035 | 0.0181 | 0.0181 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0035 | 0.0181 | 0.0473 |
Brugia malayi | Variant SH3 domain containing protein | 0.0031 | 0.0129 | 0.0337 |
Echinococcus multilocularis | NCK adaptor protein | 0.0031 | 0.0129 | 0.0129 |
Trypanosoma cruzi | choline kinase | 0.0033 | 0.0156 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0035 | 0.0181 | 0.0181 |
Brugia malayi | Variant SH3 domain containing protein | 0.0024 | 0.0049 | 0.0128 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0031 | 0.0129 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0156 | 0.0407 |
Schistosoma mansoni | vav2 | 0.0024 | 0.0049 | 0.005 |
Schistosoma mansoni | adapter molecule crk | 0.0031 | 0.0129 | 0.0131 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0035 | 0.0181 | 0.0181 |
Brugia malayi | SRC-1 | 0.0035 | 0.0181 | 0.0473 |
Schistosoma mansoni | nck2/grb4 | 0.0031 | 0.0129 | 0.0131 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0035 | 0.0181 | 0.0181 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0417 | 0.0417 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0035 | 0.0181 | 0.0181 |
Onchocerca volvulus | Putative choline\/ethanolamine kinase | 0.0033 | 0.0156 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0417 | 0.0417 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0033 | 0.0156 | 0.0407 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0035 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0343 | 0.3826 | 1 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0031 | 0.0129 | 0.0129 |
Trypanosoma brucei | choline/ethanolamine kinase | 0.0033 | 0.0156 | 0.5 |
Trichomonas vaginalis | choline/ethanolamine kinase, putative | 0.0033 | 0.0156 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0035 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0031 | 0.0129 | 0.0337 |
Schistosoma mansoni | development and differentiation-enhancing factor ddef | 0.0024 | 0.0044 | 0.0045 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0343 | 0.3826 | 1 |
Schistosoma mansoni | choline kinase | 0.0033 | 0.0156 | 0.0159 |
Loa Loa (eye worm) | choline Kinase A | 0.0033 | 0.0156 | 0.0407 |
Trypanosoma cruzi | choline ethanolamine kinase, putative | 0.0033 | 0.0156 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0035 | 0.0181 | 0.0184 |
Giardia lamblia | Ethanolamine kinase, putative | 0.0033 | 0.0156 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0417 | 0.0417 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0417 | 0.109 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0035 | 0.0181 | 0.0181 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0033 | 0.0156 | 0.0159 |
Echinococcus granulosus | NCK adaptor protein | 0.0031 | 0.0129 | 0.0129 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0033 | 0.0156 | 0.0159 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0035 | 0.0181 | 0.0181 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0033 | 0.0156 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0035 | 0.0181 | 0.0184 |
Echinococcus granulosus | ethanolamine kinase 2 | 0.0033 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0024 | 0.0049 | 0.0128 |
Trypanosoma brucei | choline kinase | 0.0033 | 0.0156 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0035 | 0.0181 | 0.0184 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0035 | 0.0181 | 0.0181 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0035 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0031 | 0.0129 | 0.0337 |
Echinococcus granulosus | c src tyrosine kinase | 0.0035 | 0.0181 | 0.0181 |
Onchocerca volvulus | 0.0033 | 0.0156 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0848 | 0.9819 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0035 | 0.0181 | 0.0181 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0035 | 0.0181 | 0.0181 |
Echinococcus multilocularis | arf GAP with SH3 domain, ANK repeat and PH | 0.0024 | 0.0044 | 0.0044 |
Echinococcus multilocularis | ethanolamine kinase 2 | 0.0033 | 0.0156 | 0.0156 |
Brugia malayi | Variant SH3 domain containing protein | 0.0031 | 0.0129 | 0.0337 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0031 | 0.0129 | 0.0131 |
Schistosoma mansoni | tyrosine kinase | 0.0035 | 0.0181 | 0.0184 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0417 | 0.109 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0035 | 0.0181 | 0.0181 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0031 | 0.0129 | 0.0337 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0035 | 0.0181 | 0.0181 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0031 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0033 | 0.0156 | 0.0407 |
Loa Loa (eye worm) | SRC-1 | 0.0035 | 0.0181 | 0.0473 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0129 | 0.0337 |
Echinococcus granulosus | arf GAP with SH3 domain ANK repeat and PH | 0.0024 | 0.0044 | 0.0044 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0417 | 0.0417 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.