Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | transketolase | 0.0456353 | 0.00950756 | 0.5 |
Trypanosoma cruzi | transketolase, putative | 0.0456353 | 0.00950756 | 0.5 |
Entamoeba histolytica | transketolase, putative | 0.0456353 | 0.00950756 | 1 |
Echinococcus granulosus | transketolase | 0.0456353 | 0.00950756 | 0.5 |
Plasmodium falciparum | transketolase | 0.034674 | 0.00500028 | 1 |
Trypanosoma brucei | transketolase, putative | 0.0456353 | 0.00950756 | 0.5 |
Entamoeba histolytica | transketolase, putative | 0.0456353 | 0.00950756 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0456353 | 0.00950756 | 1 |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0456353 | 0.00950756 | 1 |
Loa Loa (eye worm) | hypothetical protein | 2.45442 | 1 | 1 |
Trichomonas vaginalis | transketolase, putative | 0.0456353 | 0.00950756 | 1 |
Loa Loa (eye worm) | hypothetical protein | 1.35294 | 0.547074 | 0.542726 |
Brugia malayi | Phospholipase A2 family protein | 1.35294 | 0.547074 | 1 |
Mycobacterium ulcerans | transketolase | 0.0456353 | 0.00950756 | 1 |
Plasmodium vivax | transketolase, putative | 0.034674 | 0.00500028 | 1 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0456353 | 0.00950756 | 1 |
Toxoplasma gondii | transketolase | 0.0456353 | 0.00950756 | 1 |
Onchocerca volvulus | Phospholipase A2 homolog | 2.45442 | 1 | 1 |
Echinococcus granulosus | transketolase | 0.0456353 | 0.00950756 | 0.5 |
Schistosoma mansoni | transketolase | 0.0456353 | 0.00950756 | 0.5 |
Schistosoma mansoni | transketolase | 0.0456353 | 0.00950756 | 0.5 |
Echinococcus multilocularis | transketolase | 0.0456353 | 0.00950756 | 0.5 |
Treponema pallidum | transketolase | 0.034674 | 0.00500028 | 1 |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0456353 | 0.00950756 | 0.5 |
Trypanosoma cruzi | transketolase, putative | 0.0456353 | 0.00950756 | 0.5 |
Chlamydia trachomatis | transketolase | 0.0456353 | 0.00950756 | 1 |
Giardia lamblia | Transketolase | 0.034674 | 0.00500028 | 0.5 |
Echinococcus multilocularis | transketolase | 0.0456353 | 0.00950756 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.00000001 M | In vitro antimalarial activity of the compound against P. falciparum | ChEMBL. | 11428929 |
EC50 (functional) | = 0.000016 M | in vitro cytotoxicity of the compound against mouse mammary tumor in cell culture. | ChEMBL. | 11428929 |
EC50 (functional) | = 1 M | In vitro antimalarial activity of the compound against P. falciparum | ChEMBL. | 11428929 |
EC50 (functional) | = 1.6 M | in vitro cytotoxicity of the compound against mouse mammary tumor in cell culture. | ChEMBL. | 11428929 |
ED50 (functional) | = 160 mg kg-1 | in vivo antimalarial activity of the compound against P. berghei infected mice on intraperitoneal administration | ChEMBL. | 11428929 |
ED50 (functional) | = 160 mg kg-1 | in vivo antimalarial activity of the compound against P. berghei infected mice on intraperitoneal administration | ChEMBL. | 11428929 |
ED90 (functional) | > 200 mg kg-1 | in vivo antimalarial activity of the compound against P. berghei infected mice on intraperitoneal administration | ChEMBL. | 11428929 |
ED90 (functional) | > 200 mg kg-1 | in vivo antimalarial activity of the compound against P. berghei infected mice on intraperitoneal administration | ChEMBL. | 11428929 |
Selectivity (functional) | = 1600 | Mean of EC50 value for FM3A cells/ mean of EC50 value for P. falciparum | ChEMBL. | 11428929 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 11428929 | |
Plasmodium falciparum | ChEMBL23 | 11428929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.