Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen phosphorylase | 0.0121 | 0.5421 | 0.5019 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0121 | 0.5421 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0121 | 0.5421 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0121 | 0.5421 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1722 | 0.3176 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0121 | 0.5421 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0121 | 0.5421 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0121 | 0.5421 | 0.5019 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0052 | 0.1681 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.177 | 0.3266 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1722 | 0.3176 |
Schistosoma mansoni | glycogen phosphorylase | 0.0052 | 0.1681 | 0.095 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0808 | 0.149 |
Brugia malayi | carbohydrate phosphorylase | 0.0121 | 0.5421 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1722 | 0.3176 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0052 | 0.1681 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0808 | 0.149 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0121 | 0.5421 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0121 | 0.5421 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1722 | 0.3176 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0121 | 0.5421 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.177 | 0.3266 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.