Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1962 | 0.1271 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0226 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0095 | 0.3822 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0792 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0792 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0792 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0792 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1962 | 0.6573 |
Echinococcus granulosus | jun protein | 0.0095 | 0.3822 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0792 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.37 | 0.3158 |
Onchocerca volvulus | 0.0074 | 0.2863 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1962 | 0.5134 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0792 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0792 | 0.0524 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1962 | 0.6573 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1962 | 0.5134 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0792 | 0.5 |
Brugia malayi | hypothetical protein | 0.0074 | 0.2863 | 0.2655 |
Schistosoma mansoni | jun-related protein | 0.0077 | 0.2986 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1962 | 0.5134 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1962 | 0.5134 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1962 | 0.1728 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0792 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.2986 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0095 | 0.3822 | 0.3642 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1962 | 0.6573 |
Echinococcus multilocularis | jun protein | 0.0095 | 0.3822 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0095 | 0.3822 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.