Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0061 | 0.0777 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0061 | 0.0777 | 0.5 |
Plasmodium vivax | heat shock protein 86, putative | 0.0084 | 0.3053 | 0.5 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0084 | 0.3053 | 0.3053 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0156 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0132 | 0.7724 | 0.6724 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0061 | 0.0777 | 0.0777 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0061 | 0.0777 | 0.0777 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Plasmodium falciparum | heat shock protein 90 | 0.0084 | 0.3053 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0156 | 1 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0061 | 0.0777 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0061 | 0.0777 | 0.5 |
Treponema pallidum | heat shock protein 90 | 0.0061 | 0.0777 | 0.5 |
Echinococcus granulosus | heat shock protein 90 | 0.0084 | 0.3053 | 0.2468 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0156 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0084 | 0.3053 | 0.3053 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 1 | 1 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0084 | 0.3053 | 1 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0156 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0061 | 0.0777 | 0.2098 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0084 | 0.3053 | 0.3053 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0084 | 0.3053 | 0.3053 |
Plasmodium vivax | endoplasmin, putative | 0.0084 | 0.3053 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0061 | 0.0777 | 0.2098 |
Trichomonas vaginalis | heat shock protein, putative | 0.0061 | 0.0777 | 0.2098 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0084 | 0.3053 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0084 | 0.3053 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Echinococcus multilocularis | heat shock protein 90 | 0.0084 | 0.3053 | 0.2468 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Echinococcus multilocularis | heat shock protein | 0.0084 | 0.3053 | 0.2468 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0156 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0084 | 0.3053 | 0.5 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0156 | 1 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0084 | 0.3053 | 0.3053 |
Echinococcus granulosus | heat shock protein | 0.0084 | 0.3053 | 0.2468 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0084 | 0.3053 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0084 | 0.3053 | 1 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0156 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0132 | 0.7724 | 0.6724 |
Leishmania major | heat shock protein 83-1 | 0.0084 | 0.3053 | 0.2468 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.