Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor | 0.0464 | 0.3042 | 0.3335 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.1288 | 0.1288 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0244 | 0.088 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.088 | 0.088 |
Loa Loa (eye worm) | glutamate receptor | 0.0952 | 0.7838 | 0.7838 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0797 | 0.6319 | 0.6319 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1082 | 0.912 | 1 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0155 | 0 | 0.5 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0155 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0374 | 0.2162 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.1172 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0797 | 0.6319 | 0.6319 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1172 | 1 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0244 | 0.088 | 0.1122 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0862 | 0.6958 | 0.8878 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0952 | 0.7838 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0244 | 0.088 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1288 | 0.1288 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0464 | 0.3042 | 0.3881 |
Brugia malayi | hypothetical protein | 0.0286 | 0.1288 | 0.1643 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0797 | 0.6319 | 0.6929 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.1288 | 0.1288 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.01 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 30.1313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.