Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1214 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0283 | 0.2334 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1214 | 1 |
Echinococcus granulosus | mitotic checkpoint serine:threonine protein | 0.0057 | 0.0075 | 0.0076 |
Schistosoma mansoni | stomatin-related | 0.0057 | 0.0075 | 0.0621 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1214 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1214 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0283 | 0.2334 |
Loa Loa (eye worm) | serine/threonine protein kinase | 0.0057 | 0.0075 | 0.0621 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1214 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1214 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1214 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0075 | 0.0621 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1214 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1214 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1214 | 0.1219 |
Echinococcus multilocularis | mitotic checkpoint serine:threonine protein | 0.0057 | 0.0075 | 0.0076 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1214 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1214 | 0.1219 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0283 | 0.2334 |
Brugia malayi | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta | 0.0057 | 0.0075 | 0.0621 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0075 | 0.0621 |
Echinococcus multilocularis | mitotic checkpoint serine:threonine protein | 0.023 | 0.996 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0075 | 0.0621 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0283 | 0.2334 |
Echinococcus granulosus | mitotic checkpoint serine:threonine protein | 0.023 | 0.996 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1214 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.