Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0602 | 0.0602 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0358 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0095 | 0.1688 | 0.1688 |
Schistosoma mansoni | tubulin subunit beta | 0.0095 | 0.1688 | 0.1688 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0358 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0095 | 0.1688 | 0.1688 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0602 | 0.0602 |
Brugia malayi | Tubulin beta-1 chain | 0.0095 | 0.1688 | 0.1688 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0602 | 0.0602 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0358 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0156 | 0.3633 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0095 | 0.1688 | 0.1688 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0358 | 1 | 1 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0358 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.3633 | 0.5 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0358 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0095 | 0.1688 | 0.1688 |
Schistosoma mansoni | tubulin subunit beta | 0.0095 | 0.1688 | 0.1688 |
Echinococcus multilocularis | 0.0358 | 1 | 1 | |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0095 | 0.1688 | 0.1688 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0602 | 0.0602 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0358 | 1 | 1 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0358 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0358 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0358 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0358 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0095 | 0.1688 | 0.1688 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0358 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0095 | 0.1688 | 0.1688 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0358 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0095 | 0.1688 | 0.1688 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0358 | 1 | 1 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0358 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0095 | 0.1688 | 0.1688 |
Loa Loa (eye worm) | BEN-1 protein | 0.0095 | 0.1688 | 0.1688 |
Brugia malayi | beta-tubulin, identical | 0.0095 | 0.1688 | 0.1688 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0095 | 0.1688 | 0.1688 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0358 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.