Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.2188 | 0.656 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.105 | 0.283 | 0.1417 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.3238 | 1 | 1 |
Mycobacterium ulcerans | hydrolase | 0.105 | 0.283 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.105 | 0.283 | 0.3666 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0862 | 0.2215 | 0.262 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1912 | 0.5655 | 0.8785 |
Loa Loa (eye worm) | hypothetical protein | 0.0862 | 0.2215 | 0.262 |
Onchocerca volvulus | 0.1181 | 0.3259 | 0.2667 | |
Loa Loa (eye worm) | hypothetical protein | 0.1007 | 0.2691 | 0.3429 |
Loa Loa (eye worm) | hypothetical protein | 0.0862 | 0.2215 | 0.262 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.1007 | 0.2691 | 0.8256 |
Schistosoma mansoni | hypothetical protein | 0.1181 | 0.3259 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.105 | 0.283 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.105 | 0.283 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0507 | 0.1051 | 0.3226 |
Loa Loa (eye worm) | matrixin family protein | 0.2188 | 0.656 | 1 |
Brugia malayi | Hemopexin family protein | 0.1181 | 0.3259 | 0.2403 |
Onchocerca volvulus | Matrilysin homolog | 0.2057 | 0.6131 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.1912 | 0.5655 | 0.8463 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.