Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | pyruvate kinase | 0.043 | 0.4962 | 0.4962 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0584 | 0.6868 | 0.6868 |
Loa Loa (eye worm) | pyruvate kinase | 0.0176 | 0.183 | 0.183 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0584 | 0.6868 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.043 | 0.4962 | 0.4962 |
Schistosoma mansoni | hypothetical protein | 0.0303 | 0.339 | 0.339 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0303 | 0.339 | 0.339 |
Echinococcus multilocularis | snurportin 1 | 0.0303 | 0.339 | 0.339 |
Echinococcus granulosus | pyruvate kinase | 0.043 | 0.4962 | 0.4962 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.0646 | 0.0646 |
Echinococcus multilocularis | pyruvate kinase | 0.043 | 0.4962 | 0.4962 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.043 | 0.4962 | 0.4962 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0253 | 0.2781 | 0.2781 |
Brugia malayi | hypothetical protein | 0.0154 | 0.1559 | 0.1559 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.043 | 0.4962 | 0.4962 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0154 | 0.1559 | 0.1559 |
Echinococcus multilocularis | pyruvate kinase | 0.043 | 0.4962 | 0.4962 |
Echinococcus granulosus | pyruvate kinase | 0.043 | 0.4962 | 0.4962 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0154 | 0.1559 | 0.1559 |
Plasmodium falciparum | pyruvate kinase 2 | 0.043 | 0.4962 | 0.4962 |
Echinococcus granulosus | snurportin 1 | 0.0303 | 0.339 | 0.339 |
Brugia malayi | pyruvate kinase, muscle isozyme | 0.0176 | 0.183 | 0.183 |
Brugia malayi | pyruvate kinase | 0.0176 | 0.183 | 0.183 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0154 | 0.1559 | 0.1559 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.1559 | 0.1559 |
Loa Loa (eye worm) | hypothetical protein | 0.0584 | 0.6868 | 0.6868 |
Echinococcus multilocularis | pyruvate kinase | 0.0661 | 0.7819 | 0.7819 |
Echinococcus multilocularis | pyruvate kinase | 0.043 | 0.4962 | 0.4962 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.