Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3432 | 0.2988 |
Schistosoma mansoni | cd36 antigen | 0.0049 | 0.29 | 0.242 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.29 | 0.242 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.0634 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.0634 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3432 | 0.2988 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3432 | 0.2988 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3432 | 0.2988 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.3432 | 0.2988 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3432 | 0.2988 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0634 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.3432 | 0.2988 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 1 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0634 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.0634 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3432 | 0.2988 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0634 | 1 |
Brugia malayi | hypothetical protein | 0.0049 | 0.29 | 0.242 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0634 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.0634 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.0634 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.29 | 0.242 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0634 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0634 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0634 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.29 | 0.242 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0634 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0634 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.0634 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3432 | 0.2988 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0634 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.0634 | 0.5 |
Brugia malayi | hypothetical protein | 0.0049 | 0.29 | 0.242 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.