Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | vesicle-fusing ATPase | 0.0912 | 0.5238 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0931 | 0.5376 | 0.5 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.1475 | 0.9407 | 1 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.1475 | 0.9407 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1475 | 0.9407 | 0.9407 |
Giardia lamblia | AAA family ATPase | 0.0931 | 0.5376 | 0.5 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.1475 | 0.9407 | 0.5 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.1555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 0.5238 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1555 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.1475 | 0.9407 | 0.5 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.1555 | 1 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.4654 | 0.4654 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0912 | 0.5238 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.4654 | 0.4654 |
Trypanosoma brucei | Valosin-containing protein | 0.1475 | 0.9407 | 0.5 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.1555 | 1 | 0.5 |
Mycobacterium ulcerans | ATPase | 0.0931 | 0.5376 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.1475 | 0.9407 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.4654 | 0.4654 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0643 | 0.3247 | 0.3247 |
Brugia malayi | valosin containing protein | 0.0912 | 0.5238 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0931 | 0.5376 | 0.0000097958 |
Toxoplasma gondii | cell division protein CDC48CY | 0.1555 | 1 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0643 | 0.3247 | 0.3247 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.1475 | 0.9407 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 0.1778 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5733 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.