Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | No references |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 477 aa | 431 aa | 34.6 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0512 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0512 | 1 | 1 |
Onchocerca volvulus | 0.0512 | 1 | 1 | |
Loa Loa (eye worm) | tyrosinase 1 | 0.0512 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0512 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0268 | 0.3001 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0178 | 0.0423 | 0.0423 |
Schistosoma mansoni | tyrosinase precursor | 0.0512 | 1 | 0.5 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0512 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0512 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0512 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0512 | 1 | 0.5 |
Onchocerca volvulus | 0.0512 | 1 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0512 | 1 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0268 | 0.3001 | 0.5 |
Onchocerca volvulus | 0.0512 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0512 | 1 | 1 |
Onchocerca volvulus | 0.0512 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0512 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.72 | Inhibition of MMP3 (unknown origin) | ChEMBL. | 17275314 |
Ki (binding) | = 0.19 uM | Inhibitory activity against human stromelysin-3 (MMP-3) | ChEMBL. | No reference |
Ki (binding) | = 0.19 uM | Inhibitory activity against human stromelysin-3 (MMP-3) | ChEMBL. | No reference |
Ki (binding) | = 0.22 uM | Inhibitory activity against human gelatinase-A (MMP-2) | ChEMBL. | No reference |
Ki (binding) | = 0.22 uM | Inhibitory activity against human gelatinase-A (MMP-2) | ChEMBL. | No reference |
Ki (binding) | = 0.87 uM | Inhibitory activity against human collagenase (MMP-1) | ChEMBL. | No reference |
Ki (binding) | = 0.87 uM | Inhibitory activity against human collagenase (MMP-1) | ChEMBL. | No reference |
log(1/Ki) (binding) | = 6.72 | Inhibition of MMP3 (unknown origin) | ChEMBL. | 17275314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.