Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.3462 | 0.9062 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.3777 | 1 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.0534 | 0.0334 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.3777 | 1 | 0.5 |
Echinococcus granulosus | integrin beta 2 | 0.0534 | 0.0334 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.3777 | 1 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0725 | 0.0905 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 240 nM | Reversal of sensivity of multidrug resistant chinese hamster ovary cell line CHRC/5 expressed as concentration that restores 50% of cytotoxic activity of 5 ug/mL toward doxorubicin | ChEMBL. | 7608906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.