Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.4 nM | Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes. | ChEMBL. | 7636873 |
IC50 (binding) | = 1.4 nM | Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes. | ChEMBL. | 7636873 |
Ki (binding) | = -0.04 | Cannabinoid receptor 1 binding affinity by measuring its ability to displace [3H]-WIN-55,212-2 in rat forebrain membranes | ChEMBL. | 9804691 |
Ki (binding) | = -0.04 | Binding affinity at cannabinoid receptor 1 using rat brain membranes | ChEMBL. | 11448223 |
Log Ki (binding) | = -0.04 | Cannabinoid receptor 1 binding affinity by measuring its ability to displace [3H]-WIN-55,212-2 in rat forebrain membranes | ChEMBL. | 9804691 |
Log Ki (binding) | = -0.04 | Binding affinity at cannabinoid receptor 1 using rat brain membranes | ChEMBL. | 11448223 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.