Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0439 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0045 | 0 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.0249 | 0.518 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5108 | 0.5108 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase | 0.0249 | 0.518 | 0.518 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Loa Loa (eye worm) | TK protein kinase | 0.0249 | 0.518 | 0.518 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase | 0.0249 | 0.518 | 0.518 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus multilocularis | serotonin receptor | 0.0439 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0439 | 1 | 1 |
Schistosoma mansoni | amine GPCR | 0.0359 | 0.7991 | 0.7991 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0045 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.