Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.3281 | 0.3571 |
Onchocerca volvulus | 0.0262 | 0.5074 | 0.5 | |
Brugia malayi | Glutamate receptor 2 precursor | 0.0178 | 0.2784 | 0.2784 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.3281 | 0.3571 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0378 | 0.8191 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0178 | 0.2784 | 0.3399 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0109 | 0.0935 | 0.0935 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0178 | 0.2784 | 0.292 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0178 | 0.2784 | 0.2784 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0378 | 0.8191 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0196 | 0.3281 | 0.3571 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0178 | 0.2784 | 0.3399 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.4123 | 0.4123 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0109 | 0.0935 | 0.0935 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.4919 | 0.4919 |
Trichomonas vaginalis | set domain proteins, putative | 0.0262 | 0.5074 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.3281 | 0.3571 |
Schistosoma mansoni | hypothetical protein | 0.0372 | 0.8028 | 0.9801 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0196 | 0.3281 | 0.3571 |
Brugia malayi | hypothetical protein | 0.0257 | 0.4919 | 0.4919 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0161 | 0.2332 | 0.2328 |
Brugia malayi | Pre-SET motif family protein | 0.0231 | 0.4213 | 0.4213 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0935 | 0.0935 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0114 | 0.1051 | 0.0651 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0231 | 0.4213 | 0.4213 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0178 | 0.2784 | 0.2784 |
Schistosoma mansoni | hypothetical protein | 0.0372 | 0.8028 | 0.9801 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.3281 | 0.3571 |
Schistosoma mansoni | glutamate receptor kainate | 0.0178 | 0.2784 | 0.3399 |
Schistosoma mansoni | glutamate receptor kainate | 0.0178 | 0.2784 | 0.3399 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0257 | 0.4919 | 0.5716 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0196 | 0.3281 | 0.3571 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0196 | 0.3281 | 0.3571 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.3281 | 0.3571 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.025 | 0.473 | 0.5 |
Echinococcus granulosus | geminin | 0.0372 | 0.8028 | 0.9787 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0291 | 0.5856 | 0.7149 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0378 | 0.8191 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0114 | 0.1051 | 0.0651 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0178 | 0.2784 | 0.3399 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.3281 | 0.3571 |
Echinococcus granulosus | glutamate receptor 2 | 0.013 | 0.1503 | 0.1243 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0257 | 0.4919 | 0.5716 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0109 | 0.0935 | 0.0935 |
Echinococcus multilocularis | geminin | 0.0372 | 0.8028 | 0.9787 |
Schistosoma mansoni | glutamate receptor kainate | 0.0178 | 0.2784 | 0.3399 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0161 | 0.2332 | 0.2328 |
Echinococcus multilocularis | glutamate receptor 2 | 0.013 | 0.1503 | 0.1243 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0178 | 0.2784 | 0.2784 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates | ChEMBL. | 1975275 |
IC50 (binding) | > 10000 nM | In vitro inhibitory activity against [3H]-TCP binding to PCP receptor in guinea pig brain membrane homogenates | ChEMBL. | 1975275 |
IC50 (binding) | > 100000 nM | In vitro inhibitory activity against [3H]-DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates | ChEMBL. | 1975275 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.