Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0153 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0153 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0153 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 100 mg kg-1 | Concentration required to prevent seizures upon intraperitoneal administration in mice in MES (maximal electroshock seizure) test. | ChEMBL. | 1875341 |
ED50 (functional) | > 100 mg kg-1 | Concentration required to prevent seizures upon intraperitoneal administration in mice in MES (maximal electroshock seizure) test. | ChEMBL. | 1875341 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.