Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.266 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4188 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.4188 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5303 | 0.5303 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.266 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.1485 | 0.1485 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.266 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5303 | 0.4483 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4188 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.266 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.266 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.266 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4188 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.266 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.266 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.1485 | 0.1485 |
Brugia malayi | hypothetical protein | 0.0037 | 0.4188 | 0.4188 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.4188 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.266 | 0.266 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4188 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.1485 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5303 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.266 | 0.138 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.