Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.