Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | 0.01 | 0.3263 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0122 | 0.434 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0093 | 0.2964 | 0.2964 |
Brugia malayi | RNase H family protein | 0.0065 | 0.1629 | 0.2614 |
Toxoplasma gondii | ribonuclease HI protein | 0.0094 | 0.3006 | 0.5 |
Echinococcus multilocularis | ribonuclease H1 | 0.0093 | 0.2964 | 0.8686 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0845 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0243 | 1 | 1 |
Leishmania major | ribonuclease H1, putative | 0.0094 | 0.3006 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0051 | 0.0983 | 0.0983 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0065 | 0.1629 | 0.5 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0845 | 0.0477 |
Trypanosoma brucei | ribonuclease H1 | 0.0122 | 0.434 | 0.3023 |
Echinococcus granulosus | tumor protein p63 | 0.01 | 0.3263 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0122 | 0.434 | 0.5 |
Brugia malayi | RNase H family protein | 0.0065 | 0.1629 | 0.2614 |
Brugia malayi | RNase H family protein | 0.0122 | 0.434 | 1 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0094 | 0.3006 | 0.5 |
Giardia lamblia | Ribonuclease H | 0.0094 | 0.3006 | 0.5 |
Echinococcus granulosus | ribonuclease H1 | 0.0093 | 0.2964 | 0.8686 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0094 | 0.3006 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0094 | 0.3006 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0065 | 0.1629 | 0.1629 |
Schistosoma mansoni | phosphoglucomutase | 0.0093 | 0.2964 | 0.2964 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0001 M | Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M | ChEMBL. | 3121857 |
IC50 (binding) | = 0.0001 M | Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M | ChEMBL. | 3121857 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.